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Discovery and repurposing of artemisinin

Frontiers of Medicine 2022, Volume 16, Issue 1, Pages 1-9 doi: 10.1007/s11684-021-0898-6

Abstract: The discovery of artemisinin, inspired by traditional Chinese medicine (TCM), has brought in a paradigmWith its high potency and low toxicity, the wide use of artemisinin effectively treats the otherwise drug-resistantHere, we will first review the initial discovery of artemisinin, an extraordinary journey that was in

Keywords： artemisinin drug repurposing cancer inflammation COVID-19 traditional Chinese medicine

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Identification of cancer stem cells provides novel tumor models for drug discovery

Douglas D. Fang, Danyi Wen, Yajun Xu

Frontiers of Medicine 2012, Volume 6, Issue 2, Pages 112-121 doi: 10.1007/s11684-012-0199-1

Abstract: Accumulating evidence suggests that CSCs are responsible for tumor initiation and progression, drug resistanceterm and its definition, and further addresses the issue of how to utilize CSCs in therapeutic target discoveryand drug development based on our substantial experience.

Keywords： cancer stem cell tumor model drug discovery

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DISCOVERY OF TRIKETONE-QUINOXALINE HYBRIDS AS POTENT HPPD INHIBITORS USING STRUCTURE-BASED DRUG DESIGN

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1, Pages 133-145 doi: 10.15302/J-FASE-2021401

Abstract: A battery of novel triketone-quinoxaline compounds has been designed using a structure-based drug design

Keywords： herbicide / HPPD / inhibitor / quinoxaline / triketon

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The Application of Artificial Intelligence Accelerates G Protein-Coupled Receptor Ligand Discovery Review

Wei Chen,Chi Song,Liang Leng,Sanyin Zhang,Shilin Chen

Engineering 2024, Volume 32, Issue 1, Pages 19-29 doi: 10.1016/j.eng.2023.09.011

Abstract: GPCRs) are crucial players in various physiological processes, making them attractive candidates for drugdiscovery.However, traditional approaches to GPCR ligand discovery are time-consuming and resource-intensive.In this study, we provide guidelines for effectively utilizing AI methods for GPCR ligand discovery,Subsequently, the key applications of AI methods in the different stages of GPCR drug discovery were

Keywords： G protein-coupled receptor Ligand Artificial intelligence Multi-omics Drug discovery

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Artificial Intelligence in Pharmaceutical Sciences Review

Mingkun Lu, Jiayi Yin, Qi Zhu, Gaole Lin, Minjie Mou, Fuyao Liu, Ziqi Pan, Nanxin You, Xichen Lian, Fengcheng Li, Hongning Zhang, Lingyan Zheng, Wei Zhang, Hanyu Zhang, Zihao Shen, Zhen Gu, Honglin Li, Feng Zhu

Engineering 2023, Volume 27, Issue 8, Pages 37-69 doi: 10.1016/j.eng.2023.01.014

Abstract:

Drug discovery and development affects various aspects of human health and dramatically impacts theHowever, investments in a new drug often go unrewarded due to the long and complex process of drug researchDriven by big data in biomedicine, AI has led to a revolution in drug R&D, due to its ability toThis review begins with a brief overview of common AI models in the field of drug discovery; then, itas target discovery, drug discovery and design, preclinical research, automated drug synthesis, and

Keywords： Artificial intelligence Machine learning Deep learning Target identification Target discovery Drugdesign Drug discovery

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Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 490-495 doi: 10.1007/s11684-018-0647-7

Abstract: case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistantWhile most cancer therapies are given in combinations that are designed to avoid drug resistance, wetherapeutic approaches that take advantage of the changes in cancer cells that arise upon development of drugThis approach is based on notion that drug resistance comes at a fitness cost to the cancer cell thatWe discuss the development of sequential drug therapies in which the first therapy is not given with

Keywords： cancer drug resistance genetic screens senescence targeted therapy

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Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1, Pages 116-122 doi: 10.1007/s11705-013-1310-0

Abstract: acid was incorporated in the various Psy- -PMA samples and tablets were prepared to study the in vitro drugIn addition, the biodegradable Psy- -PMA had the highest drug release in the acidic medium.This may be attributed to Fickian diffusion since the drug and the medium in which it was released have

Keywords： psyllium acetyl salicylic acid in-vitro drug release swelling biodegradation

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Protein microspheres for pulmonary drug delivery

Yongda SUN,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1, Pages 82-86 doi: 10.1007/s11705-009-0307-1

Abstract: supercritical fluid (SCF) technique was developed for the preparation of microspheres for pulmonary drugleading to a dry fine powder with good particle size distribution and near ideal morphology for pulmonary drug

Keywords： advanced engineering improved pressure aqueous technique

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Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 2, Pages 225-232 doi: 10.1007/s11705-014-1429-7

Abstract: These polymers are selected based on their importance and broad scope of application in FDA-approved drugGlyceride-based polymers used in self-emulsifying drug delivery systems (SEDDS) will also be discussed

Keywords： controlled release drug delivery semi-solids polymer excipient

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Nanostructured hollow spheres of hydroxyapatite: preparation and potential application in drug delivery

Xiaojing ZHANG, Weixin ZHANG, Zeheng YANG, Zhao ZHANG

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 3, Pages 246-252 doi: 10.1007/s11705-012-1299-9

Abstract: The properties of the different kinds of spheres as drug delivery carriers were evaluated.Ibuprofen (IBU) was chosen as the model drug to load into the HA samples.The HA hollow spheres exhibited a higher drug loading capacity and more favorable release propertiesthan the HA solid spheres and thus are very promising for controlled drug release applications.

Keywords： hydroxyapatite hollow spheres synthesis drug release

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HIGH-PERFORMANCE COMPUTATION AND ARTIFICIAL INTELLIGENCE IN PESTICIDE DISCOVERY: STATUS AND OUTLOOK

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1, Pages 150-154 doi: 10.15302/J-FASE-2021419

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Antibody Therapies Targeting Complex Membrane Proteins Review

Georgina To´a Salazar, Ziyi Huang, Ningyan Zhang, Xue-Guang Zhang, Zhiqiang An,

Engineering 2021, Volume 7, Issue 11, Pages 1541-1551 doi: 10.1016/j.eng.2020.11.013

Abstract:

In analyses of protein families that may serve as drug targets, membrane-associated G-protein-coupledA better understanding of the membrane proteins being targeted would facilitate mechanism-based drugdiscovery.

Keywords： Antibody therapy Complex membrane protein Ion channels Transporters Membrane-bound enzymes GPCRs Drugdiscovery

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Liquid metal material genome: Initiation of a new research track towards discovery of advanced energy

Lei WANG, Jing LIU

Frontiers in Energy 2013, Volume 7, Issue 3, Pages 317-332 doi: 10.1007/s11708-013-0271-9

Abstract: As the basis of modern industry, the roles materials play are becoming increasingly vital in this day and age. With many superior physical properties over conventional fluids, the low melting point liquid metal material, especially room-temperature liquid metal, is recently found to be uniquely useful in a wide variety of emerging areas from energy, electronics to medical sciences. However, with the coming enormous utilization of such materials, serious issues also arise which urgently need to be addressed. A biggest concern to impede the large scale application of room-temperature liquid metal technologies is that there is currently a strong shortage of the materials and species available to meet the tough requirements such as cost, melting point, electrical and thermal conductivity, etc. Inspired by the Material Genome Initiative as issued in 2011 by the United States of America, a more specific and focused project initiative was proposed in this paper—the liquid metal material genome aimed to discover advanced new functional alloys with low melting point so as to fulfill various increasing needs. The basic schemes and road map for this new research program, which is expected to have a worldwide significance, were outlined. The theoretical strategies and experimental methods in the research and development of liquid metal material genome were introduced. Particularly, the calculation of phase diagram (CALPHAD) approach as a highly effective way for material design was discussed. Further, the first-principles (FP) calculation was suggested to combine with the statistical thermodynamics to calculate the thermodynamic functions so as to enrich the CALPHAD database of liquid metals. When the experimental data are too scarce to perform a regular treatment, the combination of FP calculation, cluster variation method (CVM) or molecular dynamics (MD), and CALPHAD, referred to as the mixed FP-CVM-CALPHAD method can be a promising way to solve the problem. Except for the theoretical strategies, several parallel processing experimental methods were also analyzed, which can help improve the efficiency of finding new liquid metal materials and reducing the cost. The liquid metal material genome proposal as initiated in this paper will accelerate the process of finding and utilization of new functional materials.

Keywords： liquid metal material genome energy material material discovery advanced material room-temperature liquid

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An econometric investigation using price discovery theory

Yeli ZENG, Cong DONG, Mikael HÖÖK, Jinhua SUN, Danyang SHI

Frontiers in Energy 2020, Volume 14, Issue 4, Pages 726-739 doi: 10.1007/s11708-020-0701-4

Abstract: reflect the average price level and market movements, but the market information transparency and price discovery

Keywords： liquefied natural gas price index Shanghai Petroleum and Gas Exchange price discovery market reforms

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Prevalence of antifolate drug resistance markers in in China

Frontiers of Medicine 2022, Volume 16, Issue 1, Pages 83-92 doi: 10.1007/s11684-021-0894-x

Abstract: dhps) genes of Plasmodium vivax and antifolate resistance-associated genes were used for drugvivax parasites were different across China and molecular markers could be used to rapidly monitor drugResults provided evidence for updating national drug policy and treatment guidelines.

Keywords： drug resistance antifolates molecular markers Plasmodium vivax China